Education

• Merck Postdoctoral Fellowship, Yale University
   
• Ph.D., Harvard University
   
• B.S., University of Chicago

Research Interests

• Catalyst screening and reaction development
   
• Asymmetric synthesis
   
• Fluorinated phosphonates
   
• Mechanism-based enzyme inhibitors
   
• PLP enzymes
   
• Lignan natural products

Recent Publications

• Stephany M. Ramos de Dios, Jared L. Hass, Danielle L. Graham, Nivesh Kumar, Aina E. Antony, Martha D. Morton and David B. Berkowitz; “Information-Rich, Dual-Function 13C/2H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme “Partitioning Fingerprint” and Reveals Disparate Chemotypes for hSR Inhibition” J. Am. Chem. Soc. 2023, 145, 3158-3174; [Link]
• Sushil K. Shakyawar; Nitish K. Mishra; Neetha N. Vellichirammal;  Lynnette Cary; Tomáš Helikar; Robert Powers; Rebecca E. Oberley-Deegan; David B. Berkowitz; Kenneth W. Bayles; Vijay K. Singh; Chittibabu Guda, “A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures” Radiation Research 2022, 198, 89-111; [Link]
• Stephany M. Ramos De Dios, Virendra K. Tiwari, Christopher D. McCune, Ranjeet A. Dhokale, and David B. Berkowitz*
  “Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization”. Chem. Rev. 2022, 121, 13800-13880;  [Link]
• Virendra K. Tiwari, Douglas R. Powell, Sylvain Broussy*, and David B. Berkowitz* “Rapid Enantioselective and Diastereoconvergent Hybrid Organic/Biocatalytic Entry into the Oseltamivir Core” J. Org. Chem. 2021, 86, 6494-6503 [Link]
• Robert Moore, Bhanwar Lal Puniya, Robert Powers, Chittibabu Guda, Kenneth W. Bayles, David B. Berkowitz & Tomáš Helikar,* “Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome” Scientific Reports 2021, 11, 5585; [Link]
• Gaurav P. Kudalkar, Virendra K. Tiwari, Joshua D. Lee, David B. Berkowitz,* “Hammett Study of Clostridium acetobutylicum Alcohol Dehydrogenase (CaADH): An Enzyme with Remarkable Substrate Promiscuity and Utility for Organic Synthesis,” Synlett, 2020, 31, 237-247;– included in a special Synlett Cluster on Biocatalysis [Link]
• Medhanjali DasGupta, Dominik Budday, Saulo H. P. de Oliveira, Peter Madzelan, Darya Marchany-Rivera, Javier Seravalli, Brandon Hayes, Raymond G. Sierra, Sebastian Boutet, Mark Hunter, Roberto Alonso-Mori, Alexander Batyuk, Jennifer Wierman, Artem Lyubimov,  Aaron S. Brewster, Nicholas K. Sauter, Brandon Hayes,  Gregory A. Applegate, Virendra Tiwari, David B. Berkowitz, Michael C. Thompson, Aina Cohen, James S. Fraser, Michael E. Wall, Henry van den Bedem,*  Mark A. Wilson* “Mix and Inject XFEL-Crystallography Reveals Gated Conformational Dynamics During Enzyme Catalysis,” PNAS, 2019, 116, 25634-25640;  [Link]