Education

• 2008, PhD in Chemical Engineering, University of New Mexico
   
• 2003, MS in Chemical Engineering, University of New Mexico
   
• 2002, BS in Chemical Engineering, University of New Mexico

Research Interests

• Combining inorganic nanomaterials with biological materials and living cells to create novel solutions to public health, agriculture, and environmental problems.
   
• Using living cells to create novel hierarchical multiscale materials by combining self-assembly and lithography with lipids, ion channels, surface receptors, and nanoparticles for biological and materials applications
   
• Using hybrid biomaterials to create artificial microenvironments that enable the study of clinical observable pathologies that are seemingly impossible to duplicate under laboratory conditions
   
• Creating organic and inorganic nanoparticles and microparticles for use in targeted delivery of cancer therapeutics and medical countermeasures for applications in public health and chemical/biological defense

Selected Publications

• Shin, S.H.R., McAninch, P.T., Henderson, I.M., Gomez, A., Greene, A.C., Carnes, E.C., Paxton, W.F.; Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH. Commun., 2018, 54, 9043-9046
   
• Butler, K. S.; Durfee, P. N.; Theron, C.; Ashley, C. E.; Carnes, E. C.; Brinker, C. J. Protocells: Modular Mesoporous Silica Nanoparticle-Supported Lipid Bilayers for Drug Delivery. Small 2016, 12, 2173-2185.
   
• Johnson, P. E.; Muttil, P.; MacKenzie, D.; Carnes, E. C.; Pelowitz, J.; Mara, N. A.; Mook, W. M.; Jett, S. D.; Dunphy, D. R.; Timmins, G. S.; Brinker, C. J. Spray-Dried Multiscale Nano-biocomposites Containing Living Cells. ACS Nano, June 2015, 9, 6961-6977.
   
• Dengler, E. C.; Liu, J.; Kerwin, A.; Torres, S.; Olcott, C. M.; Bowman, B. N.; Armijo, L.; Gentry, K.; Wilkerson, J.; Wallace, J.; Jiang, X.; Carnes, E. C.; Brinker, C. J.; Milligan, E. D.: Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord. Journal of Controlled Release 2013, 168, 209-224 (Cover).
   
• Epler, K.; Padilla, D.; Phillips, G.; Crowder, P.; Castillo, R.; Wilkinson, D.; Wilkinson, B.; Burgard, C.; Kalinich, R.; Townson, J.; Chackerian, B.; Willman, C.; Peabody, D.; Wharton, W.; Brinker, C. J.; Ashley, C.; Carnes, E.: Delivery of Ricin Toxin A-Chain by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers. Advanced Healthcare Materials 2012, 1, 348-353 (COVER).
   
• Ashley, C. E.; Carnes, E. C.; Epler, K. E.; Padilla, D. P.; Phillips, G. K.; Castillo, R. E.; Wilkinson, D. C.; Wilkinson, B. S.; Burgard, C. A.; Kalinich, R. M.; Townson, J. L.; Chackerian, B.; Willman, C. L.; Peabody, D. S.; Wharton, W.; Brinker, C. J.: Delivery of Small Interfering RNA by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers. ACS Nano 2012, 6, 2174-2188 (COVER).
   
• Ashley, C. E.; Carnes, E. C.; Phillips, G. K.; Padilla, D.; Durfee, P. N.; Brown, P. A.; Hanna, T. N.; Liu, J.; Phillips, B.; Carter, M. B.; Carroll, N. J.; Jiang, X.; Dunphy, D. R.; Willman, C. L.; Petsev, D. N.; Evans, D. G.; Parikh, A. N.; Chackerian, B.; Wharton, W.; Peabody, D. S.; Brinker, C. J.: The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. Nat Mater 2011, 10, 389-397 (COVER).
   
• Ashley, C. E.; Carnes, E. C.; Phillips, G. K.; Durfee, P. N.; Buley, M. D.; Lino, C. A.; Padilla, D. P.; Phillips, B.; Carter, M. B.; Willman, C. L.; Brinker, C. J.; Caldeira, J. d. C.; Chackerian, B.; Wharton, W.; Peabody, D. S.: Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles. ACS Nano 2011, 5, 5729-5745 (COVER).
   
• Carnes, E. C.; Lopez, D. M.; Donegan, N. P.; Cheung, A.; Gresham, H.; Timmins, G. S.; Brinker, C. J.: Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria. Nat Chem Biol 2010, 6, 41-45.
   
• Baca, H. K.; Ashley, C.; Carnes, E.; Lopez, D.; Flemming, J.; Dunphy, D.; Singh, S.; Chen, Z.; Liu, N. G.; Fan, H. Y.; Lopez, G. P.; Brozik, S. M.; Werner-Washburne, M.; Brinker, C. J.: Cell-directed assembly of lipid-silica nanostructures providing extended cell viability. Science 2006, 313, 337-341.