Forrest Kievit

Forrest Kievit.

Associate Professor
Biological Systems Engineering

262 Morrison Center
4240 Fair St
Lincoln, NE 68583
(402) 472-2175
fkievit2@unl.edu
Faculty Profile

Kievit Lab
Education
  • Ph.D. Materials Science and Engineering, University of Washington, 2011
  • B.S. Bioengineering, University of Washington, 2007

Research Interests
  • Biomedical Engineering
  • Nanomedicine
  • Nanotheranostics

Inventions/Patents
  • Forrest Kievit, Anthony Convertine, Richard Ellenbogen, Patrick Stayton, Pierre Mourad. 2015. Theranostic nanoparticles for treatment of traumatic brain injury. US Patent application 62/237,915 filed 10/6/2015.

Honors and Awards
  • UNL College of Engineering Excellence in Research (2019)
Selected Publications
  • Tarudji AW, Kievit FM. Active targeting and transport. In: Nanoparticles for Biomedical Applications, Chung EJ, Leon L, Rinaldi C, editors. Elsevier, 2020, 19-36.
  • Miller HA; Magsam AW; Tarudji AW; Romanova S; Weber L; Gee CC; Madsen GL; Bronich TK; Kievit FM. Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via Ktrans mapping with MRI. Scientific Reports 2019, 9, 1-14.
  • Bony BA; Kievit FM. A role for nanoparticles in treating traumatic brain injury. Pharmaceutics 2019, 11, 473.
  • Stephen ZR; Chiarelli PA; Revia RA; Wang K; Kievit F; Dayringer C; Jeon M; Ellenbogen R; Zhang M. Time-resolved MRI assessment of convection-enhanced delivery by targeted and nontargeted nanoparticles in a human glioblastoma mouse model. Cancer Research 2019, 79, 4776-86.
  • Yoo D; Magsam AW; Kelly AM; Stayton PS; Kievit FM*; Convertine AJ*. Core crosslinked nanoparticles reduce neuroinflammation and improve outcome in a mouse model of traumatic brain injury. ACS Nano 2017, 11, 8600-11. *co-senior authors
  • Chiarelli PA, Revia RA, Stephen ZR, Wang K, Jeon M, Nelson V, Kievit FM, Sham J, Ellenbogen RG, Kiem HP, Zhang M. Nanoparticle Biokinetics in Mice and Nonhuman Primates. ACS Nano 2017, 11, 9514-24.
  • Kievit FM; Wang K; Ozawa T; Tarudji AW; Silber JR; Holland EC; Ellenbogen RG; Zhang M. Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma. Nanomedicine: NBM 2017, 13, 2131-9.
  • J. Xu, M. Ypma, P. A. Chiarelli, J. Park, R. G. Ellenbogen, P. S. Stayton, P. D. Mourad, D. Lee, A. J. Convertine, F. M. Kievit. Theranostic Oxygen Reactive Polymers for Treatment of Traumatic Brain Injury. Adv Funct Mater. 26, 4124-33. doi: 10.1002/adfm.201504416 (2016).
  • F. M. Kievit, Z. R. Stephen, K. Wang, C. J. Dayringer, J. G. Sham, J. R. Silber, R. G. Ellenbogen, M. Zhang. Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation. Molecular Oncology 9, 1071-80 doi:10.1016/j.molonc.2015.01.006 (2015).
  • F. M. Kievit, S. J. Florczyk, M. C. Leung, K. Wang, J. D. Wu, J. R. Silber, R. G. Ellenbogen, J. S. H. Lee, M. Zhang. Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds. Biomaterials 35, 9137-43 doi:10.1016/j.biomaterials.2014.07.037 (2014).