Faculty - Kievit

Forrest Kievit, Assistant Professor

Forrest Kievit

Forrest Kievit
Assistant Professor

Department of Biological Systems Engineering
228 L.W. Chase Hall
University of Nebraska–Lincoln
Lincoln, NE 68583-0726
Office: 402-472-2175

Education

B.S. in Bioengineering, University of Washington, Seattle, 2007
Ph.D. in Materials Science and Engineering, University of Washington, Seattle, 2011
Postdoctoral Research Associate, University of Washington, Seattle; Department of Neurological Surgery, Department of Materials Science and Engineering, 2011-2013

Research Interests

  • Biomedical Engineering
  • Nanomedicine
  • Nanotheranostics

His research involves developing nanoparticle-based delivery vehicles for transport into the brain for more effective brain cancer and brain injury treatments. This stems from his career goal to help translate a nanomedicine into clinical use to improve the survival and quality of life of neurosurgery patients. The vast majority of Kievit’s research has focused on nanoparticle-mediated delivery of nucleic acids into brain tumors. Looking forward, he plans to continue developing nanoparticles that will allow for greater flexibility in therapeutic payload and disease targeting, including brain injury.

Significant Publications

  • Yoo D; Magsam AW; Kelly AM; Stayton PS; Kievit FM*; Convertine AJ*. Core crosslinked nanoparticles reduce neuroinflammation and improve outcome in a mouse model of traumatic brain injury. ACS Nano 2017, 11, 8600-11. *co-senior authors
  • Chiarelli PA, Revia RA, Stephen ZR, Wang K, Jeon M, Nelson V, Kievit FM, Sham J, Ellenbogen RG, Kiem HP, Zhang M. Nanoparticle Biokinetics in Mice and Nonhuman Primates. ACS Nano 2017, 11, 9514-24.
  • Kievit FM; Wang K; Ozawa T; Tarudji AW; Silber JR; Holland EC; Ellenbogen RG; Zhang M. Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma. Nanomedicine: NBM 2017, 13, 2131-9.
  • J. Xu, M. Ypma, P. A. Chiarelli, J. Park, R. G. Ellenbogen, P. S. Stayton, P. D. Mourad, D. Lee, A. J. Convertine, F. M. Kievit. Theranostic Oxygen Reactive Polymers for Treatment of Traumatic Brain Injury. Adv Funct Mater. 26, 4124-33. doi: 10.1002/adfm.201504416 (2016).
  • F. M. Kievit, Z. R. Stephen, K. Wang, C. J. Dayringer, J. G. Sham, J. R. Silber, R. G. Ellenbogen, M. Zhang. Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation. Molecular Oncology 9, 1071-80 doi:10.1016/j.molonc.2015.01.006 (2015).
  • F. M. Kievit, S. J. Florczyk, M. C. Leung, K. Wang, J. D. Wu, J. R. Silber, R. G. Ellenbogen, J. S. H. Lee, M. Zhang. Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds. Biomaterials 35, 9137-43 doi:10.1016/j.biomaterials.2014.07.037 (2014).
  • F. M. Kievit, Z. R. Stephen, O. Veiseh, H. Arami, T. Wang, V. P. Lai, J. O. Park, R. G. Ellenbogen, M. L. Disis and M. Zhang. Targeting of primary breast cancers and metastases in a transgenic mouse model using rationally designed multifunctional SPIONs. ACS Nano 6, 2591-601, doi:10.1021/nn205070h (2012).
  • F. M. Kievit, F. Y. Wang, C. Fang, H. Mok, K. Wang, J. R. Silber, R. G. Ellenbogen and M. Zhang. Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro. J Control Release 152, 76-83, doi:10.1016/j.jconrel.2011.01.024 (2011).
  • C. Argyropoulos, P.-Y. Chen, G. D’Aguanno, N. Engheta, and A. Alù, “Boosting Optical Nonlinearities in ε-Near-Zero Plasmonic Channels”, Physical Review B, vol. 85, pp. 045129, 2012.
  • F. M. Kievit and M. Zhang. Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery across Biological Barriers. Adv Mater 23, H217-47, doi: 10.1002/adma.201102313 (2011).